Effects of bradykinin on the systemic and coronary vascular bed of the intact dog.

• Bradykinin is a polypeptide and one of the plasma kinins. First described in 1949/ the pure product was isolated in 1960 and its identity with the original crude mixture established.3 It has vasodilator properties, stimulates smooth muscle, increases capillary permeability, and causes pain. It has been shown to increase blood flow through the forearm and skin of humans, and reduces resistance in the isolated perfused dog-lung preparation." Recently, bradykinin (among other substances) has been shown to diffuse from the skin of scalded rats. There is no integrated study of the general and coronary hemodynamic effects of bradykinin in the intact animal. Therefore, the following reports the results of such a study.